Channing J Der Selected Research

Carcinogenesis

1/2020	RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?
1/2017	Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.
10/2016	The role of wild type RAS isoforms in cancer.
12/2014	Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.
1/2014	Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
4/2012	Differential involvement of RalA and RalB in colorectal cancer.
4/2012	The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector.
9/2008	Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
3/2008	Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis.
1/2008	Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo.

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Channing J Der Research Topics

Disease

80	Neoplasms (Cancer) 01/2022 - 03/2002
13	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 12/2006
13	Carcinogenesis 01/2020 - 12/2004
10	Neoplasm Metastasis (Metastasis) 01/2021 - 08/2004
9	Breast Neoplasms (Breast Cancer) 07/2015 - 03/2004
8	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 08/2007
7	Melanoma (Melanoma, Malignant) 10/2016 - 08/2004
6	Adenocarcinoma 01/2022 - 11/2010
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2013 - 05/2008
3	Ovarian Neoplasms (Ovarian Cancer) 11/2013 - 06/2010
3	Carcinoma (Carcinomatosis) 07/2011 - 03/2002
2	Triple Negative Breast Neoplasms 01/2021 - 07/2015
2	Leukemia 08/2002 - 06/2002
1	Adenoma (Adenomas) 01/2022
1	Squamous Cell Carcinoma of Head and Neck 01/2022
1	Infections 01/2021
1	Inflammation (Inflammations) 01/2021
1	Ulcer 01/2021
1	Stomach Neoplasms (Stomach Cancer) 01/2020
1	Nevus (Nevi) 10/2016
1	Ovarian Cysts (Ovarian Cyst) 07/2011
1	Cysts 07/2011

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
19	Monomeric GTP-Binding ProteinsIBA 01/2018 - 11/2007
11	ras ProteinsIBA 01/2020 - 04/2004
10	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 08/2004
10	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 01/2018 - 06/2002
9	Protein Isoforms (Isoforms)IBA 01/2018 - 06/2007
8	GTP Phosphohydrolases (GTPases)IBA 01/2020 - 06/2002
7	Mitogen-Activated Protein KinasesIBA 01/2022 - 08/2004
7	Phosphotransferases (Kinase)IBA 11/2021 - 12/2004
6	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2022 - 03/2004
6	Oncogene Proteins (Oncogene Protein)IBA 01/2020 - 03/2013
5	Biological ProductsIBA 01/2022 - 09/2003
5	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 01/2018 - 12/2010
5	RNA (Ribonucleic Acid)IBA 01/2016 - 01/2006
5	Guanosine Triphosphate (GTP)IBA 12/2010 - 07/2004
4	Messenger RNA (mRNA)IBA 01/2022 - 01/2006
4	Protein Kinases (Protein Kinase)IBA 01/2017 - 08/2007
4	rho GTPase-activating proteinIBA 01/2016 - 05/2008
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016 - 02/2007
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 09/2014 - 08/2007
2	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2022 - 08/2002
2	Ribosomal DNA (rDNA)IBA 01/2022 - 01/2017
2	Mutant Proteins (Protein, Mutant)IBA 01/2020 - 03/2013
2	tyrosine receptor (receptor, tyrosine)IBA 10/2016 - 12/2004
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2016 - 06/2007
2	VemurafenibIBA 01/2016 - 02/2012
2	Rho Guanine Nucleotide Exchange FactorsIBA 11/2013 - 06/2002
2	Pharmaceutical PreparationsIBA 05/2013 - 01/2008
2	ErbB Receptors (EGF Receptor)IBA 11/2010 - 12/2004
2	Biomarkers (Surrogate Marker)IBA 08/2009 - 04/2009
2	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 03/2009 - 03/2008
2	Growth InhibitorsIBA 01/2008 - 01/2006
2	Estrogens (Estrogen)FDA Link 01/2008 - 01/2006
2	Estrogen Receptor alphaIBA 01/2008 - 07/2004
2	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 05/2006 - 06/2002
1	Guanine NucleotidesIBA 01/2022
1	tipifarnib (R115777)IBA 01/2022
1	Chloroquine (Aralen)FDA LinkGeneric 01/2022
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2022
1	SurvivinIBA 10/2021
1	Tubulin ModulatorsIBA 01/2021
1	CalpainIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	TubulinIBA 01/2021
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2021
1	Small Interfering RNA (siRNA)IBA 01/2021
1	tdTomatoIBA 01/2021
1	CytosineIBA 10/2020
1	SCH772984IBA 01/2020
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2020
1	ChromatinIBA 01/2017
1	Calcibiotic Root Canal SealerIBA 01/2017
1	dabrafenibIBA 01/2016
1	trametinibIBA 01/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 06/2014
1	Glucose (Dextrose)FDA LinkGeneric 02/2014
1	Glutamine (L-Glutamine)FDA Link 02/2014
1	Ras Homolog Enriched in Brain ProteinIBA 01/2014
1	Aurora Kinase AIBA 01/2014
1	MLN 8237IBA 01/2014
1	PlasticsIBA 11/2013
1	ral Guanine Nucleotide Exchange FactorIBA 04/2012
1	Protein Kinase InhibitorsIBA 02/2012
1	rho Guanine Nucleotide Dissociation Inhibitor betaIBA 07/2011
1	rho Guanine Nucleotide Dissociation Inhibitor alphaIBA 07/2011
1	matrigelIBA 07/2011
1	AgarIBA 01/2011
1	AZD 6244IBA 01/2011
1	Guanosine Diphosphate (GDP)IBA 12/2010
1	diazepinomicinIBA 11/2010
1	Monoclonal AntibodiesIBA 11/2010
1	Epidermal Growth Factor (EGF)IBA 11/2010
1	NucleotidesIBA 07/2010
1	Antineoplastic Agents (Antineoplastics)IBA 06/2010
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2010

Therapy/Procedure

20	Therapeutics 01/2022 - 08/2002
2	Precision Medicine 02/2012 - 11/2010
1	Neoadjuvant Therapy 07/2010